At the core of this guide are plans developed by local health departments that host two of NACCHO’s (National Association of County & City Health Officials) Advanced Practice Centers—cutting-edge learning laboratories that develop and test tools and resources that help local health departments continue to work on all-hazards preparedness. Santa Clara County, California and Seattle-King County, Washington, have both produced notably comprehensive, but very different, plans that describe their jurisdictions’ approaches to the threat of pandemic influenza. NACCHO recognizes that these two health departments are not necessarily representative of LHDs nationwide in terms of size and resources available. However, in the writing of this guide, NACCHO extracted the elements common to each plan, highlighting key principles and planning elements applicable to the full range of LHDs. NACCHO recognizes that a one-size-fits-all approach will not be useful given the diversity of LHDs and the jurisdictions they serve. Individual local health departments can use, modify or reject the concepts and resources provided, depending on jurisdictional specific circumstances...